Unsupervised Statistical Learning of Context-free Grammar

In this paper, we address the problem of inducing (weighted) context-free grammar (WCFG) on data given. The induction is performed by using a new model of grammatical inference, i.e., weighted Grammar-based Classifier System (wGCS). wGCS derives from learning classifier systems and searches grammar structure using a genetic algorithm and covering. Weights of rules are estimated by using a novelty Inside-Outside Contrastive Estimation algorithm. The proposed method employs direct negative evidence and learns WCFG both form positive and negative samples. Results of experiments on three synthetic context-free languages show that wGCS is competitive with other statistical-based method for unsupervised CFG learning

Fixed points of nonnegative neural networks

We consider the existence of fixed points of nonnegative neural networks, i.e., neural networks that take as an input and produce as an output nonnegative vectors. We first show that nonnegative neural networks with nonnegative weights and biases can be recognized as monotonic and (weakly) scalable functions within the framework of nonlinear Perron-Frobenius theory. This fact enables us to provide conditions for the existence of fixed points of nonnegative neural networks, and these conditions are weaker than those obtained recently using arguments in convex analysis. Furthermore, we prove that the shape of the fixed point set of nonnegative neural networks with nonnegative weights and biases is an interval, which under mild conditions degenerates to a point. These results are then used to obtain the existence of fixed points of more general types of nonnegative neural networks. The results of this paper contribute to the understanding of the behavior of autoencoders, and they provide insight into neural networks designed using the loop-unrolling technique, which can be seen as a fixed point searching algorithm. The chief theoretical results of this paper are verified in numerical simulations.Comment: 34 page

The site mapping of Kakucs-Turján by the means of horizontal and vertical proxies: Combining field and basic laboratory methods of geoarchaeology and archaeological prospection

The homogenous cultural identity that emerged during the Middle Bronze Age (2000–1450 cal BC) in the central territory of the Carpathian Basin is identified uniformly as the Vatya culture. The Vatya people created multilayered tells, open air horizontal, as well as fortified settlements along the western and eastern bank of the Danube river. These archaeological sites are significant elements of both the cultural and natural heritage of the Carpathian Basin. Their significance does not only lie within the possibility to reconstruct the life, society and material culture of Vatya populations, but the buried soils and anthropogenic sediments hold significant information on prehistoric human-environment interactions, and on site formation processes that occurred after the abandonment of the individual settlements. Geophysical prospection methods and field walking helped to locate and identify the tripartite structure of Kakucs-Turján archaeological site within the territory of the Danube–Tisza Interfluve. The settlement was established on the border of different geographical micro-regions and at the conjunction of dissimilar natural geographical environments. The stratigraphy of the site was described by the means of high resolution and focused series of hand auger observations, as well as on the basis of basic soil physical and chemical parameters. The detailed macro-morphological description of the soil core profiles aimed at precisely identifying the soilscape of the site and its vicinity, the stratigraphy of the anthropogenic and natural sediments of the settlement, but also to facilitate our understanding of the site formation process. Data gained by the means of geoarchaeological methods not only form the basis of environmental historical conclusions, but reveals mosaics of the interaction between ancient human populations and their environment. 1. Introduction 1.1. Archaeological background One of the most distinctive traits of the Middle Bronze Age (MBA; ca. 2000–1450 cal BC) in the central basin of the Danube (and in a broader context across the entire Carpathian Basin) was the dynamic development of fortified settlements (Earle and Kristiansen, 2010; Jaeger, 2016). Some of the settlements functioned uninterruptedly for a number of centuries; as a result, the current thickness of cultural layers ranges from several to over 10 m (...)27Journal of Archaeological Science: Report

POM/EVA Blends with Future Utility in Fused Deposition Modeling

Polyoxymethylene (POM) is one of the most popular thermoplastic polymers used in the industry. Therefore, the interest in its potential applications in rapid prototyping is understandable. Nevertheless, its low dimensional stability causes the warping of 3D prints, limiting its applications. This research aimed to evaluate the effects of POM modification with ethylene-vinyl acetate (EVA) (2.5, 5.0, and 7.5 wt.%) on its processing (by melt flow index), structure (by X-ray microcomputed tomography), and properties (by static tensile tests, surface resistance, contact angle measurements, differential scanning calorimetry, and thermogravimetric analysis), as well as very rarely analyzed emissions of volatile organic compounds (VOCs) (by headspace analysis). Performed modifications decreased stiffness and strength of the material, simultaneously enhancing its ductility, which simultaneously increased the toughness even by more than 50% for 7.5 wt.% EVA loading. Such an effect was related to an improved linear flow rate resulting in a lack of defects inside the samples. The decrease of the melting temperature and the slight increase of thermal stability after the addition of EVA broadened the processing window for 3D printing. The 3D printing trials on two different printers showed that the addition of EVA copolymer increased the possibility of a successful print without defects, giving space for further development

Multi-epoch VLBI of a double maser super burst

In a rare and spectacular display, two well-known massive star forming regions, W49N and G25.65+1.05, recently underwent maser 'super burst' - their fluxes suddenly increasing above 30,000 and 18,000 Jy, respectively, reaching several orders of magnitude above their usual values. In quick-response, ToO observations with the EVN, VLBA and KaVA were obtained constituting a 4 week campaign - producing a high-cadence multi-epoch VLBI investigation of the maser emission. The combination of high-resolution, polarisation and flux monitoring during the burst provides one of the best accounts, to date, of the maser super burst phenomenon, aiding their use as astrophysical tools. These proceedings contain the preliminary results of our campaign

Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms

Protein-protein interactions (PPIs) govern intracellular life, and identification of PPI inhibitors is challenging. Roadblocks in assay development stemming from weak binding affinities of natural PPIs impede progress in this field. We postulated that enhancing binding affinity of natural PPIs via protein engineering will aid assay development and hit discovery. This proof-of-principle study targets PPI between linear ubiquitin chains and NEMO UBAN domain, which activates NF-κB signaling. Using phage display, we generated ubiquitin variants that bind to the functional UBAN epitope with high affinity, act as competitive inhibitors, and structurally maintain the existing PPI interface. When utilized in assay development, variants enable generation of robust cell-based assays for chemical screening. Top compounds identified using this approach directly bind to UBAN and dampen NF-κB signaling. This study illustrates advantages of integrating protein engineering and chemical screening in hit identification, a development that we anticipate will have wide application in drug discovery

Outcome of Second Primary Malignancies Developing in Multiple Myeloma Patients

Background: There is an increased risk of second primary malignancies (SMPs) in patients with multiple myeloma (MM). This multinational 'real-world' retrospective study analyzed the characteristics and outcomes of MM patients that developed SPMs.Results: 165 patients were analyzed: 62.4% males; 8.5% with a prior cancer; 113 with solid SPMs, mainly =stage 2; and 52 with hematological SPM (hemato-SPM), mainly MDS/AML. Patients with hemato-SPM were younger (p = 0.05) and more frequently had a prior AutoHCT (p = 0.012). The time to SPM was shorter in the older (>65 years) and more heavily pretreated patients. One hundred patients were actively treated at the time of SPM detection. Treatment was discontinued in 52, substituted with another anti-MM therapy in 15, and continued in 33 patients. Treatment discontinuation was predominant in the patients diagnosed with hemato-SPM (76%). The median OS following SPM detection was 8.5 months, and the main cause of death was SPM. A poor ECOG status predicted a shorter OS (PS 3 vs. 0, HR = 5.74, 2.32-14.21, p < 0.001), whereas a normal hemoglobin level (HR = 0.43, 0.19-0.95, p = 0.037) predicted longer OS.Conclusions: With the continuing improvement in OS, a higher proportion of MM patients might develop SPM. The OS following SPM diagnosis is poor; hence, frequent surveillance and early detection are imperative to improve outcomes

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe